1. • Hypersensitivity to ingredients (albumin, sodium chloride, botulinum toxin)
3. • Neuromuscular disease (myasthenia gravis, Easton-Lambert Syndrome, motor neuro disease)
5. • Patients treated with botox concurrent with other drugs that interfere with neuromuscular transmission: antibiotics (i.e. certain animoglycosides, lincosamides polymixins), penicillamine, quinine, calcium channel blockers, neuromuscular blocking agents (i.e. atracurium, succinylcholine), anticholinesterases, magnesium sulphate, and quinidine – all may increase the paralytic effect of the toxin (also potentially other serologic types of botulinum)
7. • Pregnancy / lactation
9. • Patients on anticoagulation therapy/ aspirin (relative contraindication)
11. • Inappropriate anatomy (skin laxity, photo-damage)
13. • Poor psychological adjustments, unrealistic expectations

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